h1 bulletClinical Research



21 Published Studies About Neuropathy - the Data is Compelling


Anodyne® Therapy is one of the few evidence based infrared light therapy modalities on the market today. In addition to the extensive amount of published evidence on the effects of infrared therapy devices with similar wavelengths (810nm-940nm), there have been 12 published peer reviewed studies demonstrating positive effects of Anodyne® Therapy for the treatment of neuropathy symptoms. To review any of the articles below, simply click on either "abstract" or "full text pdf".


JAPMA 2002 - Symptomatic Reversal of Peripheral Neuropathy in Patients With Diabetes Abstract Full Text PDF
Endocrine Practice 2004 - Improvement of Sensory Impairment in Patients with Peripheral Neuropathy Abstract Full Text PDF
Diabetes Care - 2004 - Restoration of Sensation, Reduced Pain, and Improved Balance in Subjects with DPN Abstract Full Text PDF
Journal of Geriatric PT 2004 - MIRE and Physical Therapy for PN: Influence on Sensation, Balance, and Falls Abstract Full Text PDF
JAPMA 2005 - Improved Sensitivity in Patients with Peripheral Neuropathy Abstract Full Text PDF
Age and Ageing 2006 - Reversal of Diabetic Peripheral Neuropathy with MIRE Decreases Falls and the Fear of Falling and Improves Activities of Daily Living in Seniors Abstract Full Text PDF
Physical and Occupational Therapy in Geriatrics 2006 - Effectiveness of MIRE and Physical Therapy for Peripheral Neuropathy: Changes in Sensation, Pain, and Balance Abstract Full Text PDF
Journal of Diabetes and Its Complications 2006 - Improved Foot Sensitivity and Pain Reduction in Patients with Peripheral Neuropathy After Treatment with MIRE Abstract Full Text PDF
Practical Pain Management 2007 - Infrared Photo Energy May Reduce Neuropathic Pain Abstract Full Text PDF



Click here to learn how Anodyne® Therapy compares to Laser (LLLT)




The mechanism of action underlying neuropathic pain relief associated with MIRE may be due, in part, to a combination of topical heat and an increased local release of nitric oxide that has been reported using this wavelength (890nm) of near infrared light energy. The source of released nitric oxide may be endothelial cells or red blood cells, or both.

Clinical Research has linked nitric oxide with:


Increases in local circulation
Reduction of pain
Reduction in inflammation


Collagen synthesis


Nitric oxide production is compromised in both type 1 and type 2 diabetic patients. If near infrared light is able to favorably alter local nitric oxide availability in the diabetic patient, this may improve microcirculation via an alteration of cGMP-mediated vasodilation at the site of treatment. Better blood flow may, in part, explain the symptomatic decrease in pain these patients.


Nitric oxide also appears to be able to mitigate pain via a mechanism similar to morphine, namely via nitric oxide mediated production of cGMP and phosphorylation of ATP-dependent potassium channel activity. There may be a significant analgesic effect of MIRE if local concentrations of nitric oxide are increased. To review more information about nitric oxide, and its role in health and diabetes - please click on the links below.


Part 1 - Discovery of NO, Nobel Prize, Relevance in Vasodilation

Part 2 - Isoforms of Nitric Oxide Synthase

Part 3 - Nitric Oxide Metabolism in Diabetic Patients

Part 4 - How Nitric Oxide Causes Vasodilation

Part 5 - Nitric Oxide and Neurotransmission

Part 6 - Nitric Oxide's Effects on Proliferation/ Differentiation: Fibroblasts, Blood Vessels (Angiogenesis), and Skin

Part 7 - Nitric Oxide and Relief of Pain

Part 8 - Nitric Oxide (NO) and Diabetic Peripheral Neuropathy (DPN)

Part 9 - Now Infrared Light May Increase Local NO and Vasodilation

Part 10 - The Current Science and Benefit of Nitric Oxide and Diabetes




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Anodyne® Therapy Increases Local Circulation


Circulation increases to various parts of the body were measured by a Moor Scanning Laser Doppler after a 20 - 30 minute Anodyne® Therapy treatments.


On the pictures below, the increases in circulation are shown in vivid colors. The percentage change was determined by changes in blood flux for each subject - pre and post Anodyne® Therapy Treatment.


heel2 heel1
Heel Up to 3200% increase

back2 back1
Lower Back Up to 1300% increase

elbow1 elbow2
Elbow Up to 1300% increase

knee2 knee1
Knee Up to 2000% increase



The following series of images compares Anodyne® Therapy treatments (infrared + topical heat) to treatment with a topical heating pad. Subjects were tested for 35 minutes, and then their circulation was measured 4 hours POST treatment. As you can see, Subject #1 (Anodyne) still had a blood flux increase of 164% 4 hours post treatment, and Subject #2 had a 45% decrease in blood flux after only 2 hours post treatment!


Anodyne® Therapy Systems vs. Heating Pad

Pre Scan
Delayed Post Scan
Pre Scan Anodyne
4 hours after >> Anodyne® Therapy
Post Scan Anodyne